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Siena, like other Tuscan hill towns, was first settled in the time of the Etruscans (c. 900 BC to 400 BC) when it was inhabited by a tribe called the Saina.

Siena's cathedral, the Duomo, begun in the twelfth century, is one of the great examples of Italian romanesque architecture. Its main façade was completed in 1380. It is unusual for a Christian cathedral in that its axis runs north-south. This is because it was originally intended to be the largest cathedral in existence, with a north-south transept and an east-west aisle, as is usual. After the completion of the transept and the building of the east wall (which still exists and may be climbed by the public via an internal staircase) the money ran out and the rest of the cathedral was abandoned.

Inside is the famous Gothic octagonal pulpit by Nicola Pisano (1266–1268) supported on lions, and the labyrinth inlaid in the flooring, traversed by penitents on their knees. Within the Sacristy are some perfectly preserved renaissance frescos by Ghirlandaio, and beneath the Duomo in the baptistry is the marvelous baptismal font with bas-reliefs by Donatello, Ghiberti, Jacopo della Quercia and other 15th century sculptors. The Museo dell'Opera del Duomo contains Duccio's famous Maestà (1308–1311) and various other works by Sienese masters. More Sienese paintings are to be found in the Pinacoteca.

The shell-shaped Piazza del Campo, the town square, which houses the Palazzo Pubblico and the Torre del Mangia, is another architectural treasure, and is famous for hosting the Palio horse race. The Palazzo Pubblico, itself a great work of architecture, houses yet another important art museum. Included within the museum is Ambrogio Lorenzetti's series of frescos on the good government and the results of good and bad government and also some of the finest frescoes of Simone Martini and Pietro Lorenzetti.

Housed in the notable Gothic Palazzo Chigi on Via di Città is the Accademia Musicale Chigiana, Siena's conservatory of music.

Other churches in the city include: Basilica dell'Osservanza, Santa Maria dei Servi, San Domenico, San Francesco, Santo Spirito, San Martino, Sanctuary of Santa Caterina, incorporating the old house of St. Catherine of Siena. It houses the miraculous Crucifix (late 12th century) from which the saint received her stigmata, and a 15th century statue of St. Catherine.
The city's gardens include the Orto Botanico dell'Università di Siena, a botanical garden maintained by the University of Siena.

Fonte: Wikipedia